Diamine Oxidase use as an anti-inflammatory dietary supplement
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Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Université Mouloud Mammeri
Abstract
Histamine intolerance (HIT) has beenthe subjectofmany scientific studiesand is thought to be caused by a reduced intestinal degradation of this amine. The enzyme diamine oxidase (DAO) is considered for the gastrointestinal degradation of histamine. Histamine is an essential mediator of the pathophysiology of many allergic diseases. The inflammatory response is one of the effects exerted by histamine through its different receptors (H1, H2, H3, H4). The aim of this bibliographic review was to assess the efficacy of a new approach by implementing DAO enzyme as food supplementation in a preventive treatment for patients diagnosed with histamine intolerance. First we focused on reviewing the main sources of DAO (bacterial, vegetal and animal), discussing the process of extraction from known sources such as L. sativus and Porcine Kidney, and purification of plant and animal based DAO. We then reviewed and discussed the anti-inflammatory properties of the enzyme, which showed a significant reduction of every HIT-related symptom and its intensity due to DAO oral supplements.
Description
49 p. : ill. ; 30 cm. (+ CD-Rom)
Keywords
DAO, Histamine, Amine oxidases, Inflammatory response, Histamine intolerance, Oral supplements
Citation
Option : Nutritional Biochemistry